The adverse drug reactions to tumor necrosis factor alpha inhibitor

Results In total, 111 subjects were enrolled. Mean age was 39.8¡3⁄411.7 years, and male was 68.5%. The diagnoses of subjects were AS (62.2%), RA (24%), CD (17%), and pyoderma gangrenosum (0.9%). The injected agents were adalimumab (53.2%), etanercept (29%), and infliximab (20.7%). Adverse drug reactions of 30.6% were reported. The most common adverse reactions were cutaneous reactions; 10 (9.0%) eczema, 4 (3.6%) injection site reaction, and 2 (1.8%) urticaria. 3.6% of subjects had a slight increase in liver enzyme, and pulmonary tuberculosis occurred in 2 (1.8%) patients. Mean therapy duration prior to adverse reactions was 2.1¡3⁄42.2 years. Serious adverse reaction, anaphylaxis, growth retardation, and Henoch-Schönlein purpura occurred in one patient each. Conclusion This study shows that the adverse reactions to TNFa inhibitors were frequent, but most of them were mild reactions and the most common adverse reaction was cutaneous reactions.